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July 10, 2023Journal of the Endocrine SocietyOpen Access

23 patients received surgical treatment with 2 perioperative deaths; 21 were alive at median 7.0 years follow-up, with 3 developing local recurrence or metastasis (all SDH-deficient).

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Why the study?

Paragangliomas located within the pericardium represent a rare yet challenging clinical situation, warranting description of their clinical characteristics, diagnostic approach, genetic background, and multidisciplinary management.

Population

24 patients diagnosed with cardiac paraganglioma at a single center

Design

Single-center retrospective case series

Follow-up

Median 7.0 years (range 0.6-18 years)

Authors

CSChuan ShiJLJianzhou LiuZZZheng-pei Zeng

Discussion

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Overview

Multidisciplinary care remains key for cardiac paragangliomas; this series leaves open standardized diagnostic and genetic protocols.

Structured PICO

P
Population
24 patients diagnosed with cardiac paraganglioma (PGL) in Peking Union Medical College Hospital, Beijing, China, between 2003 and 2021. Median age 38 years, 33% female.
I
Intervention
Multidisciplinary management including medical preparation, surgery, and follow-up
O
Outcome
Clinical characteristics, diagnostic approach, genetic background, and multidisciplinary management outcomes

Cardiac paragangliomas require a multidisciplinary approach including genetic screening, surgery, and long-term follow-up due to recurrence risks, particularly in SDH-deficient tumors.

Cite This Study

Shi et al. (2023) studied this question.

synapsesocial.com/papers/6a8a739caf6b08ee8d72368ahttps://doi.org/10.1210/jendso/bvad093
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