The azole-based antifungal drugs econazole and miconazole are readily converted into imidazolidene carbenes, which are trapped by coordination to iridium(I). The resulting complexes are the first antifungal drug−metal conjugates incorporating an M−C σ bond. This demonstration of the capacity of azole-containing bioactive molecules to form carbene ligands may open the door to the investigation of complexes derived from such species for a variety of biological and medicinal purposes.
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Davis et al. (1998) studied this question.
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