Why the study?
Does ganglioside treatment facilitate recovery after CNS damage in animal models?
Does ganglioside treatment facilitate recovery after CNS damage in animal models?
Ganglioside treatment shows potential in facilitating functional recovery and reducing injury in animal models of CNS damage.
Should not change clinical practice; leaves open translation of ganglioside benefits from animal CNS models to humans.
Increased attention has focused on the use of brain gangliosides as a treatment for brain injury. This review traces the progression of in vitro and in vivo research which led to studies which have demonstrated that ganglioside treatment can facilitate recovery after CNS damage in animal models (for example, lesions, transections, hypoxia, ischemia). Hypotheses regarding the ability of gangliosides to stimulate neuronal plasticity, modulate trophic factors and reduce injury processes are presented.
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Karpiak et al. (1987) studied this question.
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