All articles of this category The diene moiety (C 9 -C 18 ) of amphidinolide B, a potent cytotoxic macrolide isolated from the marine dinoflagellate Amphidinium sp., has been synthesized by a coupling reaction of an alkynyl anion of 5 and the aldehyde 7 , followed by Michael addition and methylenation. marine natural products - Amphidinolide B - cytotoxic activity
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Ohi et al. (1999) studied this question.