All articles of this category The top-half fragment (C 14 -C 25 ) of amphidinolide B, a potent cytotoxic macrolide isolated from the marine dinoflagellate Amphidinium sp., has been synthesized using a coupling reaction of iodide 16 corresponding to the C 14 -C 19 part and α,β-unsaturated dithioacetal 9 possessing the remaining carbon framework (C 20 -C 25 ) as the key step. marine natural products - Amphidinolide B - cytotoxic activity - umpolung - asymmetric dihydroxylation
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Ohi et al. (1999) studied this question.