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Abstract
The perspective by Jasper Rine ("Twists in the tale of the aging yeast," 18 Nov. 2005, p. 1124) shows a serious lack of knowledge about the history and ideas of the aging field. Rine attempts to reconcile recent contrasting claims about yeast replicative aging and calorie restriction (CR). Several labs have shown that SIR2 and its paralogs are essential for the longevity induced by CR (1, 2), whereas Kaeberlein et al. have suggested that it is not SIR2, but rather the TOR pathway, that is essential (3).
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Cite This Study
Sinclair et al. (2006) studied this question.