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December 13, 1986BMJOpen Access

Role of vagal neuropathy in the hyponatraemia of alcoholic cirrhosis.

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Why the study?

Does vagal neuropathy contribute to hyponatraemia in patients with alcoholic cirrhosis?

Population

34 patients with cirrhosis and 64 patients with cirrhosis and ascitic decompensation

Comparison

Alcoholic cirrhosis and/or vagal neuropathy vs Non-alcoholic cirrhosis and/or absence of vagal…

Design

Cohort

Authors

GDGuy DecauxUniversité Libre de BruxellesPCP. CauchieHôpital Civil de CharleroiASAlain SoupartSt. Joseph Hospital

Discussion

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Implication

Vagal neuropathy in alcoholic cirrhosis is associated with an increased incidence of hyponatraemia, likely due to inappropriate antidiuretic hormone secretion.

Structured PICO

Does vagal neuropathy contribute to hyponatraemia in patients with alcoholic cirrhosis?

P
Population
34 patients with cirrhosis (prospective study) and 64 patients with cirrhosis and ascitic decompensation (retrospective study)
I
Intervention
Alcoholic cirrhosis and/or vagal neuropathy
C
Comparator
Non-alcoholic cirrhosis and/or absence of vagal neuropathy
O
Outcome
Incidence of hyponatraemiasurrogate

Vagal neuropathy in alcoholic cirrhosis is associated with an increased incidence of hyponatraemia, likely due to inappropriate antidiuretic hormone secretion.

Cite This Study

Decaux et al. (1986) studied this question.

synapsesocial.com/papers/6a8a7783755d28965dfd6b9ahttps://doi.org/10.1136/bmj.293.6561.1534
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac Denervation in Diabetes1973 · 623 citations
  2. 2Immediate heart-rate response to standing: simple test for autonomic neuropathy in diabetes.1978 · 426 citations
  3. 3Mechanism of the Antidiuretic Effect Associated with Interruption of Parasympathetic Pathways1972 · 77 citations
  4. 4Effective plasma volume in cirrhosis with ascites. Evidence that a decreased value does not account for renal sodium retention, a spontaneous reduction in glomerular filtration rate (GFR), and a fall in GFR during drug-induced diuresis1969 · 113 citations
  5. 5Hypouremia in the Syndrome of Inappropriate Secretion of Antidiuretic Hormone1980 · 65 citations