Why the study?
Is increased exertional dyspnea in patients with post-pulmonary embolism syndrome associated with elevated inspiratory neural drive during exercise compared to healthy controls?
Is increased exertional dyspnea in patients with post-pulmonary embolism syndrome associated with elevated inspiratory neural drive during exercise compared to healthy controls?
Elevated inspiratory neural drive to the diaphragm during exercise helps explain exertional dyspnea in patients with post-pulmonary embolism syndrome without overt pulmonary hypertension.
Elevated IND may underlie post-PE dyspnea; hypothesis-generating, needs prospective validation before clinical adoption.
This study is the first to show that increased exertional dyspnea in patients with post-pulmonary embolism (PE) syndrome, without overt pulmonary hypertension, was strongly associated with elevated inspiratory neural drive (IND) to the diaphragm during exercise, compared with healthy controls. The greater IND was associated with impairments in pulmonary gas exchange and significant deconditioning. Our results help to explain why many patients with post-PE syndrome report significant dyspnea at relatively low levels of physical activity.
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Milne et al. (2023) studied this question.
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