Why the study?
Do topical ophthalmic timolol formulations reduce maximum exercise heart rate in healthy subjects?
Do topical ophthalmic timolol formulations reduce maximum exercise heart rate in healthy subjects?
Once-daily topical ophthalmic timolol formulations produce significant systemic beta-blockade, reducing maximum exercise heart rate in healthy subjects.
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Topical timolol reduces maximum exercise heart rate; confirms systemic beta-blockade and supports caution in patients with cardiovascular disease.
Stewart et al. (1999) studied this question.