This paper describes the direct C–H bond cyanation of 2-phenylpyridines employing N,N-dimethylformamide (DMF) as both the reagent and solvent. DMF provides both the C and N units in the generated “CN” group in this cyanation transformation. This reaction gives a novel protocol with high atom economy to extend the application of DMF and provides an alternative approach to aryl nitriles.
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Yan et al. (2014) studied this question.