The asymmetric syntheses of 6-deoxyerythronolide B ( 1 ) and oleandolide ( 2 ) have been achieved, each in 18 linear steps. These syntheses demonstrate the utility of chiral β-keto imide building block 3 as a versatile building block for the aldol-based assemblage of polypropionate-derived natural products.
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Evans et al. (1998) studied this question.
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