Eptifibatide can induce acute profound thrombocytopenia and refractory hypotension mediated by eptifibatide-dependent antibodies.
Alerts to rare eptifibatide-induced thrombocytopenia with hypotension; leaves open incidence, testing utility, and prevention strategies.
A 61-year-old woman presented with acute coronary syndrome and was given heparin and eptifibatide in conjunction with coronary angioplasty. Shortly thereafter she became profoundly thrombocytopenic (platelets 2.0 x 10(9)/L) and developed severe refractory hypotension. Heparin-induced antibodies were not detected, but the patient developed strong eptifibatide-dependent antibodies specific for platelets that appear to explain both the thrombocytopenia and the hypotensive episode.
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Rezkalla et al. (2002) studied this question.
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