This case demonstrates the successful management of tirofiban-induced profound thrombocytopenia during urgent on-pump cardiac surgery, utilizing a flow cytometric assay for definitive diagnosis.
May guide diagnosis of GPIIb/IIIa-induced thrombocytopenia amid heparin antibodies in urgent cardiac surgery; hypothesis-generating and requires validation.
We describe the case of a 69-year-old man who developed glycoprotein IIb/IIIa receptor (GPIIb/IIIa) antagonist associated thrombocytopenia and the successful management during urgent aortic dissection and coronary artery bypass grafting. A flow cytometric assay was developed to confirm the diagnosis of GPIIb/IIIa-antagonist induced thrombocytopenia. This case was further complicated by the concomitant presence of heparine/PF4 platelet antibodies, but was proven not to be the causal factor of the thrombocytopenia.
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Stefan et al. (2013) studied this question.
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