Why the study?
Does corticosteroid therapy improve clinical symptoms and CEA values in a patient with hypereosinophilia and elevated CEA?
Does corticosteroid therapy improve clinical symptoms and CEA values in a patient with hypereosinophilia and elevated CEA?
Corticosteroid therapy improved clinical symptoms and reduced CEA levels in a patient with hypereosinophilia, suggesting a pathophysiological link between the disease activity and CEA changes.
We report a case of hypereosinophilia associated with increased serum levels of carcinoembryonic antigen (CEA). The patient developed fever, diarrhea, erythroderma and eosinophilia. Disorders known to be associated with eosinophilia were not detected. The typical malignant diseases related to a rise in CEA levels were not identified. The CEA value reached a maximum of 81.4 ng/ml a few weeks late for the peak of the eosinophilic count. Corticosteroid therapy was effective in improving clinical symptoms and the CEA values decreased in association with the improvement of those manifestations, suggesting a pathophysiological link between the disease activity of hypereosinophilia and the changes in CEA level.
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Iwata et al. (2008) studied this question.
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