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Fungal resistance to the limited existing antifungal agents has become a considerable public health problem in the past few decades. However, natural products with multiple bioactivities are important sources for developing new therapeutic agents against fungi. Consequently, there is an urgent need to grasp the antifungal mechanism of natural products. In this review, the primary antifungal mechanisms of natural products derived from plants, including targeting the cell wall, cell membrane, mitochondria, biofilm and other mechanisms, are elaborated. This article critically describes the compounds with high antifungal activity, revealing opportunities for future research such as clinical trials or utilization as environmental disinfectants.
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Long et al. (2024) studied this question.
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