Why the study?
Epithelioid vascular tumors pose significant diagnostic challenges, both among themselves and against other nonvascular epithelioid neoplasms, while recent immunohistochemical markers and genetic characterizations continue to advance the field.
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Design
Review
New IHC/genetic tools refine epithelioid vascular tumor diagnosis; leaves open standardized integration into practice pending validation.
Vascular tumors are a diagnostically challenging area. This is particularly true in the case of epithelioid vascular tumors. Not only is the distinction between different epithelioid vascular tumors challenging, but also the differential diagnosis may be substantially expanded by the inclusion of melanoma, carcinomas, and other epithelioid soft tissue tumors. Recently developed immunohistochemical markers and more comprehensive genetic characterizations continue to advance our understanding of epithelioid vascular tumors. The present paper briefly reviews and updates basic concepts with regard to the following epithelioid vascular tumors: epithelioid hemangioma, epithelioid angiomatous nodule, pseudomyogenic hemangioendothelioma, composite hemangioendothelioma, epithelioid hemangioendothelioma, and epithelioid angiosarcoma.
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Shon et al. (2019) studied this question.
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