In rabbit isolated blood vessels, nifedipine antagonizes the purinergic component of sympathetic vasoconstriction while the alpha 1-adrenoceptor-mediated response remains relatively resistant.
Nifedipine may selectively modulate purinergic sympathetic vasoconstriction; hypothesis-generating in animal vessels and leaves open human translation.
Antagonist drugs were used to separate the purinergic and adrenergic contributions as well as the adrenoceptor sub-types involved in the sympathetic vasoconstrictor responses produced by electrical field stimulation in rabbit isolated ileocolic and proximal saphenous arteries. Blocking drugs were applied either alone or in various combinations and sequences. 2. Nifedipine attenuated vasoconstrictor responses to sympathetic nerve stimulation both in the presence and in the absence of alpha-adrenoceptor blocking agents. However in the presence of alpha,beta-methylene ATP, nifedipine produces at best only a small attenuation of the vasoconstrictor response. 3. These results suggest that the purinergic component of the response to sympathetic nerve stimulation, at least in these tissues, can be antagonized by nifedipine, whereas the alpha 1-adrenoceptor-mediated response is relatively resistant.
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Bulloch et al. (1991) studied this question.
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