Pertussis toxin-sensitive GTP-binding proteins play a role in transducing angiotensin II-receptor occupancy into the opening of calcium channels in adrenal glomerulosa cells.
Suggests pertussis toxin-sensitive G proteins link Ang II receptors to calcium channels in glomerulosa cells; leaves open in vivo and human relevance.
Involvement of GTP-binding proteins in angiotensin II-induced mobilization of calcium has been examined in adrenal glomerulosa cells by using pertussis toxin. Pretreatment of glomerulosa cells with pertussis toxin abolishes angiotensin II-induced calcium influx without blocking inositol trisphosphate production. These results suggest a role of the pertussis toxin-sensitive GTP-binding protein in transducing angiotensin II-receptor occupancy into opening of calcium channel.
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Kojima et al. (1986) studied this question.
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