Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 25, 2024Scientific ReportsOpen Access

ASPP2 deficiency promotes the progression of metabolic dysfunction-associated steatohepatitis via ACSL4 upregulation

View Full Paper
Ask AI
Bookmark
Share

Why the study?

The mechanistic role of apoptosis-stimulating protein p53 2 (ASPP2) in the development of metabolic dysfunction-associated steatohepatitis remains elusive.

Population

Mouse model of MASH and an oleic acid-induced HepG2 cellular model

Comparison

ASPP2 deficiency vs control

Design

Preclinical animal and cell study

Authors

JWJinming WangQLQuanwei LiYHYunfei Huo

Discussion

Loading...

Member takes

Overview

May inform MASH therapies; leaves open translation from animal models to human disease.

Structured PICO

P
Population
Mouse model of metabolic dysfunction-associated steatohepatitis (MASH) and a cellular model of metabolic dysfunction-associated fatty liver disease (HepG2 cells induced by oleic acid)
I
Intervention
ASPP2 deficiency
C
Comparator
Control/wild-type
O
Outcome
MASH progression, inflammatory response, and steatosissurrogate

ASPP2 deficiency promotes MASH progression through ACSL4 upregulation, identifying a potential mechanistic pathway and therapeutic target for MASH.

Cite This Study

Wang et al. (2024) studied this question.

synapsesocial.com/papers/6a8a8de71fb56efa37d4aa3dhttps://doi.org/10.1038/s41598-024-80415-0
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ACSS2-KAT5 complex-driven histone crotonylation orchestrates a pro-inflammatory program to promote the transition from MASLD to MASH2026
  2. 2Enhancing ASPP2 promotes acute liver injury via an inflammatory immunoregulatory mechanism2024
  3. 3Lipidome profiling in advanced metabolic liver disease identifies phosphatidylserine synthase 1 as a regulator of hepatic lipoprotein metabolism2024 · 11 citations
  4. 4Identifying the Crucial Biomarker of MASH-Related HCC2024 · 2 citations
  5. 5The deubiquitinase USP28 maintains the expression of PPARγ and its inactivation protects mice from diet-induced MASH and hepatocarcinoma2025 · 10 citations