Experimental methodology demonstrates mild difluorination of heterobenzylic C–H bonds in pyridines, indicating a practical route for modifying drug-like molecules.
Difluorination of heterobenzylic C–H bonds in N-heterocycles presented by pyridines was developed using a fluorinating reagent (NFC: N -fluoro- N -(fluorosulfonyl)carbamate) under mild reaction conditions.
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Adachi et al. (2023) studied this question.
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