Exophthalmos of Graves' Disease: A Summary of the Present Status of Therapy

Article1 March 1958EXOPHTHALMOS OF GRAVES' DISEASE: A SUMMARY OF THE PRESENT STATUS OF THERAPYE. PERRY MCCULLAGH, M.D., F.A.C.P., MARVIN CLAMEN, M.D., W. JAMES GARDNER, M.D., ROSCOE J. KENNEDY, M.D., GEORGE LOCKHART III, M.D.E. PERRY MCCULLAGH, M.D., F.A.C.P.Search for more papers by this author, MARVIN CLAMEN, M.D.Search for more papers by this author, W. JAMES GARDNER, M.D.Search for more papers by this author, ROSCOE J. KENNEDY, M.D.Search for more papers by this author, GEORGE LOCKHART III, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-3-445 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGraves' disease may be considered to be a thyroid-pituitary syndrome. The two chief manifestations of the disorder are exophthalmos and hyperplastic goiter with hyperthyroidism. They usually are concurrent but may be totally dissociated, either one preceding the other. Sometimes exophthalmos is the only manifestation of the disease.In Graves' disease the termexophthalmosdesignates not only proptosis but also various associated manifestations, such as lid retraction and other changes associated with increase in bulk of the periocular tissues. This increase is due to increase in fat and in mucopolysaccharides, and sometimes to apparent edema, although the studies of Rundle and...Bibliography1. RundlePochin FFEE: Orbital tissues in thyrotoxicosis; quantitative analysis relating to exophthalmos, Clin. Sc. 5: 51 (Aug.) 1944. Google Scholar2. RundleFinlay-JonesNoad FFLRKB: Malignant exophthalmos; quantitative analysis of orbital tissues, Australasian Ann. Med. 2: 128 (Nov.) 1953. CrossrefMedlineGoogle Scholar3. DobynsWilson BMLA: An exophthalmos-producing substance in serum of patients suffering from progressive exophthalmos, J. Clin. 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DrekterHeislerScismSternPearsonMcGavack IJAGRSSTH: Determination of urinary steroids; preparation of pigment-free extracts and simplified procedure for estimation of total 17-ketosteroids, J. Clin. Endocrinol. 12: 55 (Jan.) 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 12, 1957.From the Departments of Endocrinology, Neurological Surgery, and Ophthalmology, The Cleveland Clinic Foundation, and The Frank E. Bunts Educational Institute, Cleveland, Ohio.Requests for reprints should be addressed to E. Perry McCullagh, M.D., Cleveland Clinic, 2020 East Ninety-third Street, Cleveland 6, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDie Strahlentherapie gutartiger Erkrankungen innersekretorischer DrüsenDie Strahlentherapie gutartiger Erkrankungen innersekretorischer DrüsenAdrenal steroid therapy of severe infiltrative ophthalmopathy of Graves' diseaseExperimental Studies on Exophthalmos* *From the Departments of Ophthalmology and Anatomy, College of Physicians and Surgeons, Columbia University, New York.Endocrine Exophthalmos�ber die Hemmung des experimentellen endokrinen Exophthalmus durch Lithospermum officinale 1 March 1958Volume 48, Issue 3Page: 445-470KeywordsAdrenocorticotropic hormoneEdemaEndocrinologyEstrogensFatsHypertensionHyperthyroidismOphthalmologySurgeryThyroid Issue Published: 1 March 1958 CopyrightCopyright, ©, 1958, by The American College of PhysiciansPDF DownloadLoading ...