End-Column Electrochemical Detection for Capillary Electrophoresis

Amperometric and voltammetric techniques are very attractive for detection in capillary electrophoresis (CE). The low limits of detection attainable with capillary electrophoresis-electrochemical detection (CE-ED) are a definite advantage over the widely used on-column UV detection for CE. To fully exploit the potential of CE-ED and to make it accessible to the non-specialist, robust and user-friendly detector devices have to be developed. This article reviews recent advances in the field of end-column CE-ED which can be operated without the implementation of an electrical-field decoupler. Emphasis is given on the discussion of methodical aspects and on the design of decoupler-free detector configurations that are promising to enhance the practicality of CE-ED.