Goiters in Twins Resulting From Propylthiouracil Given During Pregnancy

Case Reports1 January 1957GOITERS IN TWINS RESULTING FROM PROPYLTHIOURACIL GIVEN DURING PREGNANCYLEROY K. BRANCH, M.D., SANFORD W. TUTHILL, M.D.LEROY K. BRANCH, M.D.Search for more papers by this author, SANFORD W. TUTHILL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-1-145 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThese cases warrant comment since no report has appeared in which twins were born with goiters iatrogenically produced with propylthiouracil and iodine. No clinical evidence of hypothyroidism appeared in the infants.CASE REPORTA three months pregnant, 41 year old white female had complained of increasing nervousness, severe palpitation, easier fatigue, weakness and increased sweating for several months. There was no history of diarrhea, heat intolerance, insomnia or previous symptoms to suggest thyroid dysfunction. Examination revealed an apprehensive patient with a resting pulse rate of 138 beats per minute. After one hour's rest the pulse rate was 120. A mild...Bibliography1. FreieslebenKjerulf-Jensen EK: The effect of thiouracil derivatives on fetuses and infants, J. Clin. Endocrinol. 7: 47, 1947. CrossrefGoogle Scholar2. Morris D: Transient hypothyroidism in a newborn infant, Lancet 1: 1284, 1953. CrossrefMedlineGoogle Scholar3. Blattner RJ: Hyperthyroidism, J. Pediat. 40: 679 (May) 1952. CrossrefMedlineGoogle Scholar4. Hepner WR: Thiourea derivatives and the fetus; a review and report of a case, Am. J. Obstet. and Gynec. 63: 869-873 (Apr.) 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bogalusa, Louisiana*Received for publication July 18, 1955.From the Department of Pediatrics, Tulane University School of Medicine, and the Department of Medicine, Louisiana State University School of Medicine, New Orleans, Louisiana.Requests for reprints should be addressed to S. W. Tuthill, M.D., 201 Louisiana Avenue, Bogalusa, Louisiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPropylthiouracilHyperthyroidism during PregnancyENVIRONMENTAL CARCINOGENESIS IN MAN AND ANIMALSHyperthyroidism and PregnancyDie Klinik der Mißbildungen und Mißbildungskrankheiten 1 January 1957Volume 46, Issue 1Page: 145-148KeywordsDiarrheaFatigueHeart rateHypothyroidismInfantsInsomniaPediatricsPregnancyThyroidTwins ePublished: 1 December 2008 Issue Published: 1 January 1957 PDF downloadLoading ...