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The C-1 halogenated (brominated and chlorinated) analogues of morphine, codeine and their dihydro derivatives have been synthesized by means of known and new procedures. Hitherto unknown N-demethylation of these derivatives has also been explored, and several new N-demethyl-N-substituted analogues (allyl, n-propyl) have been prepared with the aim of contributing to a better understanding of certain details of the structure-activity relationships of the morphine alkaloids.
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Hosztafi et al. (1994) studied this question.
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