Population
Mouse embryonic fibroblasts (MEFs) and myeloid dendritic cells (mDCs), including cells from IRF-3(-/-) mice
Comparison
Rotavirus infection (live and UV-treated) vs Uninfected cells, and wild-type vs IRF-3 cells
Design
Preclinical
Authors
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Rotavirus evades IFN via IRF-3 degradation in fibroblasts but not mDCs; leaves open DC sentinel function in mucosal antiviral immunity.
Rotavirus degrades IRF-3 to evade type I interferon responses in fibroblasts, but dendritic cells can still produce type I interferon and mature in response to the virus, acting as sentinels.
Douagi et al. (2007) studied this question.
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