PURPOSE: To reduce accumulation in the abdomen by MORF/cMORF pretargeting, (111)In was compared to (99m)Tc as the radiolabel. PROCEDURES: After receiving either (99m)Tc (MAG3)-cMORF or (111)In (DTPA)-cMORF, normal mice were imaged and sacrificed for pharmacokinetics. Thereafter, tumored mice were pretargeted with MORF-antibody, 48 h later were given an injection of (99m)Tc- or (111)In-cMORF, and finally were imaged repeatedly. RESULTS: The cMORF biodistribution in both normal and pretargeted tumored mice was influenced by its radiolabel. While excretion of both (99m)Tc-cMORF and (111)In-cMORF was rapid and mainly through the kidneys, about 2 % of (99m)Tc accumulated in the intestines compared to essentially no intestinal accumulation for (111)In at any time. Tumor accumulation was unchanged. CONCLUSION: In applications of MORF/cMORF pretargeting intended to image organs deep within the abdomen such as the pancreas, radiolabeling with (111)In may be superior to (99m)Tc
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Liu et al. (2009) studied this question.