SUMMARY Studies on spayed rats treated simultaneously with mixtures of oestrone and oestriol showed that at low dose levels of oestrone the minor uterine growth response produced is augmented by oestriol; at intermediate doses of oestrone the response is inhibited by oestriol. Large doses of oestrone appear to be unaffected. 16-Epioestriol would appear to show a somewhat similar pattern of activities. We believe that these data suggest that oestriol, and perhaps 16-epioestriol, may act as a sort of biological buffer for the stronger oestrogens, maintaining the uterus when titres of the stronger oestrogens are low, restricting their actions when they are relatively high.
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Edgren et al. (1960) studied this question.