Laboratory study demonstrates carbohydrate-controlled reversible self-assembly of engineered insulin molecules, indicating broad applicability for protein protraction and drug release.
Insulin with built-in pairs of boronates and polyols can produce soluble high molecular weight self-assemblies under control by carbohydrates. The illustrated principle has potential utility for general protein and peptide protraction and controlled drug release.
No takes yet. Share an insight, caveat, or question.
Høeg-Jensen et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: