Narrative review uncovers transcriptional networks controlling myofibroblast differentiation across multiple organs, highlighting targets for resolving organ fibrosis.
Key Points
To summarize transcriptional regulatory networks governing fibroblast-to-myofibroblast differentiation in hepatic stellate cells and across multiple fibrotic organ systems.
Reviewed recent literature on transcriptional networks integrating inflammatory, metabolic, and mechanical signals during tissue fibrosis.
Synthesized molecular mechanisms centered on hepatic stellate cells and compared shared pathways across the liver, lung, heart, and kidney.
Specific transcription factor networks integrate diverse extrinsic cues to coordinate fibroblast proliferation, extracellular matrix accumulation, and cell survival.
Conserved transcriptional programs determine whether tissue damage resolves naturally or advances to chronic pathological scarring.
Targeting transcription factors and upstream regulatory cascades presents viable therapeutic avenues for reversing or halting organ fibrosis.
Cite This Study
Charoenthanakitkul et al. (2026) studied this question.