Key result
Plant-derived bioactives regulate vascular function in hypertension but low bioavailability limits clinical translation.
Why the study?
Hypertension remains a major cardiovascular risk factor, and current treatments face challenges including suboptimal blood pressure control and inadequate organ protection.
Plant-derived bioactive ingredients offer promising multi-target mechanisms for hypertension management and organ protection, though clinical translation requires overcoming challenges in bioavailability and response heterogeneity.
PDBIs may extend hypertension options via multi-target mechanisms; leaves open clinical validation in trials.
Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection. Plant-derived bioactive ingredients (PDBIs), with their multi-target and multi-pathway properties, offer novel strategies for hypertension management. This review systematically examines the mechanisms of major PDBIs (flavonoids, terpenoids, alkaloids) in hypertension, focusing on their regulation of vascular function, renin-angiotensin-aldosterone system and sympathetic nervous system, water-salt homeostasis, and target organ protection. Key signaling pathways involved (NF-κB, TGF-β, MAPK, PI3K/Akt) are analyzed. Clinical translation challenges, including low bioavailability and response heterogeneity, are discussed. Future research should integrate systems pharmacology, smart delivery systems, and precision medicine to advance PDBIs from traditional use to evidence-based therapy, providing a theoretical basis for developing novel antihypertensive and organ-protective strategies.
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Deng et al. (2026) conducted a review in Hypertension. Plant-derived bioactive ingredients (PDBIs) was evaluated. Plant-derived bioactive ingredients regulate vascular function and key signaling pathways in hypertension, though clinical translation is limited by low bioavailability and response heterogeneity.
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