What does this research mean for the field?

The predicted ILD-GAP stage, which incorporates predicted postoperative pulmonary function, provides superior prognostic accuracy for 5-year overall survival compared to the conventional ILD-GAP stage in lung cancer patients with interstitial lung disease. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the prognostic value of the predicted ILD Gender–Age–Physiology (GAP) stage—incorporating predicted postoperative lung function—as a surgical indicator for patients with early-stage lung cancer and interstitial lung disease.

August 23, 2026International Journal of Clinical OncologyOpen Access

Efficacy of a new surgical indicator for lung cancer with interstitial lung disease based on the gender–age–physiology staging system

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Authors

YIYoshito Imamura KNKeita Nakanishi HHHeng Huang

Discussion

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Overview

Retrospective study shows predicted ILD-GAP stage guides resection strategy in lung cancer with interstitial lung disease, indicating improved five-year survival stratification.

Key Points

To evaluate the prognostic value of the predicted ILD Gender–Age–Physiology (GAP) stage—incorporating predicted postoperative lung function—as a surgical indicator for patients with early-stage lung cancer and interstitial lung disease.
Retrospectively analyzed 125 patients with clinical stage 1 lung cancer and interstitial lung disease who underwent surgical resection between 2011 and 2023.
Compared postoperative outcomes across surgical procedures (anatomical resection vs. wedge resection) stratified by predicted ILD-GAP stage.
The 5-year overall survival was significantly higher with anatomical resection than wedge resection in patients with predicted ILD-GAP stage ≤ 2 (75.0% vs. 21.3%, p < 0.001), but showed no difference in stage 3 (27.8% vs. 21.3%, p = 0.934).
Multivariate analysis identified anatomical resection with predicted ILD-GAP stage ≤ 2 (p = 0.009), diffusing capacity of carbon monoxide (p = 0.043), and pathological stage 1 (p = 0.035) as independent prognostic factors.
The predicted ILD-GAP staging system demonstrated significantly greater prognostic accuracy for 5-year overall survival compared to the standard ILD-GAP stage (AUC: 0.735 vs. 0.653, p = 0.040).

Cite This Study

Imamura et al. (2026) studied this question.

synapsesocial.com/papers/6a8aadc57677a3411444631b https://doi.org/10.1007/s10147-026-03164-2

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August 23, 2026International Journal of Clinical OncologyOpen Access

Efficacy of a new surgical indicator for lung cancer with interstitial lung disease based on the gender–age–physiology staging system

View Full Paper

Ask AI

Bookmark

Authors

YIYoshito Imamura KNKeita Nakanishi HHHeng Huang

Discussion

Member takes

Overview

Retrospective study shows predicted ILD-GAP stage guides resection strategy in lung cancer with interstitial lung disease, indicating improved five-year survival stratification.

Key Points

To evaluate the prognostic value of the predicted ILD Gender–Age–Physiology (GAP) stage—incorporating predicted postoperative lung function—as a surgical indicator for patients with early-stage lung cancer and interstitial lung disease.
Retrospectively analyzed 125 patients with clinical stage 1 lung cancer and interstitial lung disease who underwent surgical resection between 2011 and 2023.
Compared postoperative outcomes across surgical procedures (anatomical resection vs. wedge resection) stratified by predicted ILD-GAP stage.
The 5-year overall survival was significantly higher with anatomical resection than wedge resection in patients with predicted ILD-GAP stage ≤ 2 (75.0% vs. 21.3%, p < 0.001), but showed no difference in stage 3 (27.8% vs. 21.3%, p = 0.934).
Multivariate analysis identified anatomical resection with predicted ILD-GAP stage ≤ 2 (p = 0.009), diffusing capacity of carbon monoxide (p = 0.043), and pathological stage 1 (p = 0.035) as independent prognostic factors.
The predicted ILD-GAP staging system demonstrated significantly greater prognostic accuracy for 5-year overall survival compared to the standard ILD-GAP stage (AUC: 0.735 vs. 0.653, p = 0.040).

Cite This Study

Imamura et al. (2026) studied this question.

synapsesocial.com/papers/6a8aadc57677a3411444631b https://doi.org/10.1007/s10147-026-03164-2

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