Isolation and Proteomics of Human Skeletal Muscle Lipid Droplets Identify Anchored Mitochondria and Associated TPD52L2

Q: What does this research mean for the field?

Proteomic analysis of human skeletal muscle lipid droplets reveals the presence of anchored mitochondria and the associated protein TPD52L2. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Xiaochuan Fu; Zhihua Zhang; Lijun Jiang; Qiumin Liao; Yilu Xu; Yang Wang; Zhen Cao; Jifeng Wang; Xiaojuan Wei; Yan Gao; Yue Li; Haijun Wang; Yin Pei; Fan Hu; Shuyan Zhang; Hongchao Zhang; Xin Zhang; Pingsheng Liu

doi:10.1093/procel/pwag056

Key Points

To isolate lipid droplets from human skeletal muscle and characterize their proteome and organelle associations.
Isolated lipid droplet fractions from human skeletal muscle tissue.
Performed proteomic profiling to characterize lipid droplet-associated proteins and interacting organellar structures.
Identified mitochondria anchored directly to lipid droplets in human skeletal muscle.
Determined that tumor protein D52-like 2 (TPD52L2) is specifically associated with the lipid droplet-mitochondria interface.

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Implication

Proteomic analysis reveals anchored mitochondria and TPD52L2 in human skeletal muscle lipid droplets, indicating close structural contacts between energy organelles.

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Cite This Study

Fu et al. (2026) studied this question.

synapsesocial.com/papers/6a8aadd57677a34114446421 https://doi.org/10.1093/procel/pwag056

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Isolation and Proteomics of Human Skeletal Muscle Lipid Droplets Identify Anchored Mitochondria and Associated TPD52L2

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Isolation and Proteomics of Human Skeletal Muscle Lipid Droplets Identify Anchored Mitochondria and Associated TPD52L2

Key Points

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Implication

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Cite This Study

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