Cohort study demonstrates comparable adverse birth outcomes between uninfected women and those treated with partial or full penicillin regimens, indicating potential flexibility in dosing.
In a South African antenatal cohort, an immediate test-and-treat model for syphilis of unknown duration showed that adverse birth outcomes-including stillbirth and preterm birth-were similar between women without syphilis and those treated with penicillin, regardless of completion of the three-dose regimen. Further studies are needed to evaluate optimal treatment strategies in pregnancy.
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Babalola et al. (2026) studied this question.
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