Functional genomic study demonstrates that GmFBA5 enhances salt tolerance in soybean and yeast models, highlighting a candidate gene for crop improvement.
Fructose-1,6-bisphosphate aldolase (FBA), as a key enzyme in energy metabolism, is widely present in organisms. Although FBA genes have been characterized in numerous plant species, their functional roles in soybean remain poorly understood. In this study, a total of 14 GmFBA genes were identified at the genome-wide level. Additionally, phylogenetic analysis divided all GmFBA family members into two divergent subclades. qRT-PCR analysis revealed that most GmFBA genes were markedly responsive to PEG6000 and salt stresses, among which GmFBA5 exhibited the strongest induction under salinity treatment. The heterologous expression of GmFBA5 in yeast was performed. The results showed that GmFBA5 markedly enhanced salt tolerance of yeast cells. Association analysis identified two distinct haplotypes of GmFBA5, and Haplotype 2 significantly enhances salt tolerance in soybean. These findings provide new insights into the potential role of GmFBA5 in soybean salt stress responses and provide candidate genetic resources for salt tolerance improvement.
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Zhao et al. (2026) studied this question.
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