Loss of BECN1 does not compromise autophagosome formation but alters cargo selection and HLA-restricted antigen presentation of B cells

Q: What does this research mean for the field?

BECN1 is dispensable for autophagosome formation but plays a critical role in the cargo selection of phagophores and HLA-restricted antigen presentation in B cells. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Svenja L. Walter; Felix Baur Lermer; Sophie Buchser; Sibilla Sander; Kennith Brian Castelino; Marcel Wacker; Éanna Fennell; Lisa Rieble; Saskia von Boxberg; Sandra Schmid; Christopher A. Hess; Laure‐Anne Ligeon; Juliane Walz; Muriel Mari; Fulvio Reggiori; Jörn Dengjel; Christian Münz

doi:10.1080/15548627.2026.2719432

August 21, 2026AutophagyOpen Access

Loss of BECN1 does not compromise autophagosome formation but alters cargo selection and HLA-restricted antigen presentation of B cells

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Key Points

To investigate the requirement of BECN1 in autophagosome formation, phagophore cargo selection, and HLA-restricted antigen presentation in B cells.
Generated BECN1 knockout lymphoblastoid cell lines (LCLs) to evaluate autophagic vesicle formation.
Assessed phagophore cargo packaging and T cell-mediated immune recognition in the presence and absence of BECN1.
Loss of BECN1 does not prevent or compromise autophagosome formation.
BECN1 deficiency alters cargo selection within phagophores and diminishes HLA-restricted antigen presentation and immunosurveillance by T cells.

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Implication

Mechanistic study demonstrates that BECN1 regulates cargo selection and antigen presentation in B cells without halting autophagosome formation, indicating key roles in immunosurveillance.

Abstract

-KO LCLs by T cells. Hence, BECN1 seems to be dispensable for autophagosome formation but rather contributes to cargo selection of phagophores and immunosurveillance.

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Cite This Study

Walter et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae337677a341144470a1 https://doi.org/10.1080/15548627.2026.2719432

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Loss of BECN1 does not compromise autophagosome formation but alters cargo selection and HLA-restricted antigen presentation of B cells

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Loss of BECN1 does not compromise autophagosome formation but alters cargo selection and HLA-restricted antigen presentation of B cells

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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