Genetic sequencing reveals predominance of the CFTR intronic 5T allele in refractory chronic rhinosinusitis with nasal polyps, suggesting a role for non-standard CF variants in severe disease.
Key Points Comprehensive CFTR sequencing detects intronic and exonic variants missed by standard CF panels. The intronic 5T allele was the most common CFTR variant in refractory CRSwNP patients.
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Fastenberg et al. (2026) studied this question.
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