The fluorescence enhancement of Indocyanine Green (ICG) molecules as a function of distance from the surface of Au nanoshells (Au-NS; see image) is examined. A decrease in enhanced fluorescence of ICG with increasing distance from the Au-NS surface is observed by growing silica spacer layers of varying thicknesses to control the distance between ICG molecules and Au-NS surface.
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Bardhan et al. (2008) studied this question.
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