Key result
Among patients with left-sided breast cancer whose radiotherapy plan avoided the heart at simulation, 49.4% experienced unintended cardiac irradiation during treatment delivery.
Why the study?
What is the incidence of unintended cardiac irradiation during left-sided breast cancer radiotherapy despite virtual simulation?
Observational (n=128)
No
What is the incidence of unintended cardiac irradiation during left-sided breast cancer radiotherapy despite virtual simulation?
Despite 3D CT simulation and cardiac shielding, a significant proportion of patients receiving left-sided breast cancer radiotherapy experience unintended cardiac irradiation.
Cardiac shielding at simulation does not ensure avoidance during delivery; leaves open whether adaptive techniques reduce exposure in left-sided breast radiotherapy.
OBJECTIVE: Cardiac irradiation during left-sided breast radiotherapy may lead to deleterious cardiac side effects. Using image guided radiotherapy, it is possible to exclude the heart from treatment fields and monitor reproducibility of virtual simulation (VS) fields at treatment delivery using electronic portal imaging (EPI). Retrospectively, we evaluate the incidence of cardiac irradiation at VS and subsequent unintended cardiac irradiation during treatment. METHODS: Patients receiving left-sided radiotherapy to the breast or chest wall, treated with a glancing photon field technique during a four-month period, were included. VS images and EPIs during radiotherapy delivery were visually assessed. The presence of any portion of the heart within the treatment field at VS or during treatment was recorded. Central lung distance and maximum heart distance were recorded. RESULTS: Of 128 patients, 45 (35.1%) had any portion of the heart within the planned treatment field. Of these, inclusion of the heart was clinically unavoidable in 25 (55.6%). Of those with no heart included in the treatment fields at VS, 41 (49.4%) had presence of the heart as assessed on EPI during treatment. CONCLUSION: Unintended cardiac irradiation during left-sided breast radiotherapy treatment occurs in a sizeable proportion of patients. ADVANCES IN KNOWLEDGE: Despite the use of three-dimensional computed tomography simulation and cardiac shielding, sizeable proportions of patients receiving left-sided breast cancer radiotherapy have unintended cardiac irradiation.
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Goody et al. (2013) conducted an observational in Left-sided breast cancer (n=128). Left-sided breast cancer radiotherapy was evaluated on Incidence of unintended cardiac irradiation during treatment among patients with no heart included at simulation. Among patients with left-sided breast cancer whose radiotherapy plan avoided the heart at simulation, 49.4% experienced unintended cardiac irradiation during treatment delivery.
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