Nedocromil sodium labelled with carbon‐14 has been prepared by a Claisen reaction between diethyl [1,2‐14C]‐ethanedioate and methyl 6‐ethanoyl‐1‐ethyl‐1,4‐dihydro‐7‐hydroxy‐4‐oxo‐8‐propylquinoline‐2‐carboxylate. The 2H‐ and 3H‐labelled materials are readily prepared by rhodium(III) chloride catalysed exchange with the appropriate isotopically labelled water.
No takes yet. Share an insight, caveat, or question.
Wilkinson et al. (1985) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: