Linear oligopeptides, 60. Synthesis by the liquid‐phase method and characterization by amino acid analyses of two complete monodispersed homologous series derived from L ‐alanine (to the octapeptide) and L ‐valine (to the hexapeptide)

The synthesis by the liquid‐phase method of the two complete, monodispersed homo‐oligopeptide series having the general formula t‐Boc{article}{empty}{document}--(\ L - X--- ){document} nGly‐OPEG (I:X=Ala, n=1‐8; II: X = Val, n = 1–6) is described. The chemical purity of the various products was assessed by thin layer chromatography and amino acid analyses. The influence of chain length and steric effects on the formation of peptide bonds and their stability to acid hydrolysis is also illustrated.