Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 14, 2006Blood

Continuous signaling via PI3K isoforms β and γ is required for platelet ADP receptor function in dynamic thrombus stabilization

View Full Paper
Ask AI
Bookmark
Share

Key result

Blocking P2Y12 receptors or PI3Kbeta/gamma isoforms led to rapid disintegration of platelet aggregates, demonstrating that continuous signaling is required for dynamic thrombus stabilization.

Population

Human and murine thrombi formed on collagen under high shear conditions

Comparison

Blockade or suppression of P2Y12 receptors, PI3K… vs Unblocked/uninhibited state

Design

Preclinical

Authors

JCJudith M.E.M. CosemansIMImke C.A. MunnixRWReinhard Wetzker

Discussion

Loading...

Member takes

Overview

May inform antiplatelet strategies targeting thrombus instability; leaves open translation from animal models to clinical use.

Structured PICO

P
Population
Human and murine thrombi formed on collagen under high shear conditions
I
Intervention
Blockade or suppression of P2Y12 receptors, PI3K beta, or PI3K gamma
C
Comparator
Unblocked/uninhibited state
O
Outcome
Thrombus stability and disassemblysurrogate

Continuous outside-in signaling via P2Y12 and PI3K beta/gamma isoforms is required to maintain platelet aggregate stability, suggesting a mechanism for dynamic thrombus instability relevant to antiplatelet therapy.

Cite This Study

Cosemans et al. (2006) studied Thrombus formation. Blocking P2Y12 receptors or PI3K isoforms was evaluated on Thrombus disassembly. Blocking P2Y12 receptors or PI3Kbeta/gamma isoforms led to rapid disintegration of platelet aggregates, demonstrating that continuous signaling is required for dynamic thrombus stabilization.

synapsesocial.com/papers/6a8ac4e4f19228bbb2fb3644https://doi.org/10.1182/blood-2006-03-006338
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation2024 · 9 citations
  2. 2Thrombin binding to GPIbα induces platelet aggregation and fibrin clot retraction supported by resting αIIbβ3 interaction with polymerized fibrin2003 · 34 citations
  3. 3Dual P2Y<sub>12</sub> receptor signaling in thrombin‐stimulated platelets – involvement of phosphoinositide 3‐kinase β but not γ isoform in Ca<sup>2+</sup> mobilization and procoagulant activity2007 · 47 citations
  4. 4The roles and mechanisms of PAR4 and P2Y<sub>12</sub>/phosphatidylinositol 3‐kinase pathway in maintaining thrombin‐induced platelet aggregation2010 · 55 citations
  5. 5Integrin αIIbβ3-dependent Calcium Signals Regulate Platelet-Fibrinogen Interactions under Flow2003 · 82 citations