Asymmetric Intramolecular Allylic Amination: Straightforward Approach to Chiral C1-Substituted Tetrahydroisoquinolines

Newly introduced Pd-catalyzed asymmetric intra­molecular allylic amination provides an easy access to pharmaceutically important 1-substituted tetrahydroisoquinolines. With this aminatio­n as the key step, (R)-carnegine was synthesized in an enantio­selective manner.