Branching out: The rhodium-catalyzed enantioselective hydroamination of monosubstituted allenes with anilines permits the atom-economic synthesis of valuable branched allylic amines. In contrast to previous linear selective allene hydroaminations, a RhI/Josiphos catalyst system (see scheme; cod=1,5-cyclooctadiene, DCE=1,2-dichloroethane) allows branched allylic amines to be obtained with perfect regioselectivity, high yield, and good enantioselectivity.
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Cooke et al. (2012) studied this question.
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