The possibility that the thyroid hor? mones exert their biological effects by specifically inhibiting or stimulating key en? zymes has been most actively investigated. It was early shown (Rohrer, 1924) that the oxygen consumption of certain tissues excised from thyrotoxic animals is greater than normal. Because of the pronounced calorigenic effect of the hormones in vivo, most investigators have concentrated their efforts on those enzymes upon which the respiratory activity of the cell depends. Of these, the two enzymatic processes most extensively studied are those concerned with coupled oxidative phosphorylation and with succinate oxidation.
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Donald F. Tapley (1962) studied this question.