A New, Simple, High-Affinity Glycosidase Inhibitor: Analysis of Binding through X-ray Crystallography, Mutagenesis, and Kinetic Analysis

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA New, Simple, High-Affinity Glycosidase Inhibitor: Analysis of Binding through X-ray Crystallography, Mutagenesis, and Kinetic AnalysisSpencer J. Williams, Valerie Notenboom, Jacqueline Wicki, David R. Rose, and Stephen G. WithersView Author Information Protein Engineering Network of Centres of Excellence Department of Chemistry, University of British Columbia 2036 Main Mall, Vancouver, Canada, V6T 1Z1 Ontario Cancer Institute and Department of Medical Biophysics University of Toronto, Toronto, Canada, M5G 2M9 Cite this: J. Am. Chem. Soc. 2000, 122, 17, 4229–4230Publication Date (Web):April 14, 2000Publication History Received26 January 2000Published online14 April 2000Published inissue 1 May 2000https://pubs.acs.org/doi/10.1021/ja0002870https://doi.org/10.1021/ja0002870rapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views555Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amides,Inhibitors,Molecular structure,Substitution reactions,Transition states Get e-Alerts