Pulmonary alveolar macrophages manifest a sodium ion-potassium ion activated, magnesium ion dependent adenosine triphosphatase (ATPase) activity. The characteristics of this ATPase were investigated in subcellular fractions and in intact cells derived from rabbits and sheep. Equimolar amounts of Mg+ +and ATP were needed for maximal activation by Na+and K+. While Na+or K+alone had a little effect on ATPase, simultaneous addition of both cations, produced a 50% stimulation of basal activity. The Na+-K+, Mg++ATPase
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Carroll E. Cross (1971) studied this question.
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