Preparation of New α‐Aminophosphonate Derivatives by Kabachnik‐Fields Reaction Using a Recyclable Catalyst

A convenient and efficient synthetic method for the preparation of some new α‐aminophosphonate derivatives via a one‐pot three‐component system has been achieved using Amberlite IRC‐748 as a recyclable catalyst. This method not only provides an excellent complement for the synthesis of α‐aminophosphonates but also avoids the use of hazardous acids or expensive/toxic Lewis acids and harsh reaction conditions. Most of the synthesized compounds (4a–o) exhibited activity against bacteria/fungi strains and moderate DPPH radical scavenging activity.