We report the first (17)O quadrupole-central-transition (QCT) NMR spectroscopic study of protein-ligand complexes in solution. This work shows that it is possible to obtain high resolution (17)O NMR spectra for (17)O-labeled ligands bound to proteins. At high magnetic fields such as 21.14 T, this (17)O QCT NMR approach should be applicable to studies of all oxygen-containing functional groups in large proteins (>30 kDa).
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Zhu et al. (2009) studied this question.
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