The atomic force microscope has been used to obtain images of colloidal dispersions of liquid crystal phases of cubic and hexagonal structures in water. Particle dimensions are consistent with dynamic light scattering and cryo-TEM data. The images we present in this work demonstrate the potential application of atomic force microscopy in revealing the morphology and structure of very soft matter in situ. This implies being able to detect possible structural modifications of the liquid crystalline phase due to in situ addition of enzymes, salts, polymers, etc. This kind of observation is not possible with other conventional high-resolution techniques.
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Neto et al. (1999) studied this question.
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