Key result
An iron-enriched diet combined with repeated blood withdrawals significantly increased liver DNA synthesis after partial hepatectomy compared to a standard diet (2.36 vs 1.21 kBq/mg DNA, p<0.05).
Why the study?
Does an iron-enriched diet combined with repeated blood withdrawals improve liver DNA synthesis and immune function in rats undergoing partial hepatectomy?
Does an iron-enriched diet combined with repeated blood withdrawals improve liver DNA synthesis and immune function in rats undergoing partial hepatectomy?
Pre-operative repeated blood withdrawals combined with an iron-enriched diet improved liver regeneration and polymorphonuclear function in a rat model of partial hepatectomy.
UNLABELLED: The aim of this study was to find the influence of blood withdrawals and diet iron on elective surgery. Male Wistar rats (n=24) were divided: 1. group (SLD) ate standard laboratory diet (SLD), 2. group (FE) an iron enriched diet (FE) with one blood withdrawal after 9 weeks. 3. group (SLD-w) SLD and 4. group (FE-w) ate the FE diet; with 9 withdrawals once a week. The rats were sacrificed 18 hour after partial hepatectomy (PH) in the 10th week. Liver DNA synthesis (3H-thymidin - kBq/mg DNA) was performed. Serum hepcidin (pg/ml), iron concentration, respiratory burst of polymorfonucleares (RB, spontaneous; stimulated, %), count of blood cells were determined. FE-w had a higher (2.36+/-0.36) liver DNA synthesis after PH vs. SLD (1.21+/-0.49). Higher hemoglobin in erythrocytes (pg) was in FE-w and SLD-w vs. FE and SLD. PMN count in SLD-w, FE-w increased vs. SLD, FE. Hepcidin after PH decreased in SLD (78.0), FE (68.0), FE-w (97.0), but increased in SLD-w (217). Serum iron increased in SLD-w. RB after PH increased in FE-w (4.5; 47.6) vs. SLD (1.15; 29.1), FE (3.20;17.8), SLD-w (3.30;13.7). CONCLUSIONS: The iron diet with stimulation of haematopoesis by withdrawals improves an organism's condition expressed as better response to elective surgery and better PMN functions.
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Živná et al. (2007) studied Elective surgery (partial hepatectomy model) (n=24). Iron-enriched diet and repeated blood withdrawals vs. Standard laboratory diet with a single blood withdrawal was evaluated on Liver DNA synthesis 18 hours after partial hepatectomy (kBq/mg DNA) (p=<0.05). An iron-enriched diet combined with repeated blood withdrawals significantly increased liver DNA synthesis after partial hepatectomy compared to a standard diet (2.36 vs 1.21 kBq/mg DNA, p<0.05).
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